Evaluation of response to different COVID-19 vaccines in vaccinated healthcare workers in a single center in IranArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] adenoviral-vectored vaccine Administered administration age anti-SARS-CoV-2 Anti-spike anti-spike antibody antibody Antibody Response average blood sample calculated center coronavirus disease Covaxin COVID-19 COVID-19 infection COVID-19 vaccine Cutoff ELISA evaluated Frequency healthcare worker individual Iran men Neutralizing antibodies neutralizing antibody neutralizing antibody. outcome Oxford/AstraZeneca pandemic participant participated positive proportion second dose significantly higher single center Sinopharm Sputnik V vaccination Vaccine Vaccines [DOI] 10.1002/jmv.28029 PMC 바로가기
The association between adverse reactions and immune response against SARS-CoV-2 spike protein after vaccination with BNT162b2 among healthcare workers in a single healthcare system: a prospective observational cohort study단일 의료 시스템에서 의료 종사자들 사이에서 BNT162b2 백신 접종 후 SARS-CoV-2 스파이크 단백질에 대한 부작용과 면역 반응 사이의 연관성: 전향적 관찰 코호트 연구Observational Study Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 임상, 진단, [키워드] administration Adverse Adverse reaction Anti-spike IgG antibody anti-spike IgG level Antibody titer association Asthma BNT162b2 BNT162b2 vaccine conducted COVID-19 Cutoff determine Factor first dose healthcare healthcare worker help humoral humoral immune response Humoral response IgG IgG level immune response information Local majority median median age mRNA mRNA vaccine of BNT162b2 participant Participants prospective observational cohort reaction recipients recruited reported SARS-CoV-2 anti-spike IgG SARS-CoV-2 spike protein second dose significantly higher systemic adverse reactions Systemic adverse reactions. systemic reaction vaccination Vaccine was collected were measured with COVID-19 women [DOI] 10.1080/21645515.2022.2048559 PMC 바로가기 [Article Type] Observational Study
Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 VirusesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome Analysis approach approach authorization BAU Beta binding antibody unit Canada CCP characterized Chicago Chicago IL clinical trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma Cutoff Delta disease course drug Emergency EUA evaluated Evidence experiment FDA food Gamma highest hospitalized patient Humoral immunity identify IgG immune IMPROVE Mann-Whitney U method comparisons Neutralization assay Neutralizing neutralizing antibody outcome Patient patient group plaque reduction neutralization plaque reduction neutralization. plasma PRNT quantitative determination required SARS-CoV-2 SARS-CoV-2 antibody selected significantly specimen tested the SARS-CoV-2 time-consuming treat United State utilization variant VLP VoC wild-type with COVID-19 [DOI] 10.1128/spectrum.02811-22 PMC 바로가기
Diagnostic utility of the Covichem score in predicting COVID-19 diseaseResearch article Published on 2022-10-012022-10-05 Journal: The American journal of emergency medicine [Category] 진단, [키워드] Accuracy Admission AUC calculated Comorbidities Covichem score COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient Cutoff demographic data diagnostic disease severity estimate evaluate evaluated external validation high risk ICU ICU admission identifying in-hospital mortality intensive care laboratory result management median Mortality objective Oxygen requirement Patient performed predicted Prognosis reached resource Result sensitivity severity significantly higher specificity the patient threshold utility validation study vital signs were recorded [DOI] 10.1016/j.ajem.2022.07.025 [Article Type] Research article
Rational Design and Development of SARS-CoV-2 Serological Diagnostics by Immunoprecipitation-Targeted ProteomicsArticle Published on 2022-09-272022-11-15 Journal: Analytical Chemistry [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] anti-RBD anti-SARS-CoV-2 antibody approach Combination convalescent convalescent plasma COVID-19 cross-reactivity current Cutoff detect development diagnostic Diseases domain elevated facilitate highest human immunoglobulin IgA IgA2 IGD IgE IgG IgG1 IgG2 IgG3 IgG4 IgM immune response immunoassay Immunoglobulin include isotype lack limit of detection limitation offer plasma Protein proteomic proteomics quantification Saliva SARS-CoV-2 serological Serological assay serological test serum significantly Simultaneous Standardization suggested [DOI] 10.1021/acs.analchem.2c01325 PMC 바로가기
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19Article Published on 2022-09-142022-11-15 Journal: Critical Care [Category] SARS, 치료기술, [키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization [DOI] 10.1186/s13054-022-04153-3 PMC 바로가기
Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts두 개의 다른 코호트에서 상용 SARS-CoV-2 대리 중화 분석과 전체 바이러스 종말점 희석 중화 테스트의 비교Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody titers biosafety level Cohort cohorts convalescent Convalescent SARS-CoV-2-infected individuals COVID COVID vaccinated individuals Cutoff detect Determination Dilution Endpoint Full virus neutralization test glycoprotein gold gold standard indicate infected individuals Infection Interaction labor labor-intensive level 3 neutralization Neutralization assay neutralization test neutralization tests Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Qualitative quantitative measurement RBD Receptor binding domain receptor protein Replication SARS-CoV-2 SARS-CoV-2-infected individual spike glycoprotein surrogate surrogate virus neutralization test Surrogate virus neutralization test. sVNT the RBD vaccinated individuals Viral viral spike virus Virus neutralization virus neutralization test VNT [DOI] 10.1016/j.jviromet.2022.114569 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses to Vector, Mix-and-Match, or mRNA Vaccines against SARS-CoV-2 and the Relationship between the Two Immune ResponsesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] Abbott acute respiratory syndrome Affect affected affecting age age and sex analyzed anti-SARS-CoV-2 antibody Antibody detection BAU binding antibody unit BNT162b2 cellular Cellular immune response cellular immune responses ChAdOx1 nCoV-19 coronavirus correlation Cutoff demonstrated determine Effect Elecsy evaluated Factor female first vaccination Genscript group humoral humoral immune responses immune immune response immune responses interferon gamma investigated male mix-and-match vaccine mRNA mRNA vaccine mRNA-1273 neutralizing antibody predict Qiagen QuantiFERON RBD regimen regimens relationship response robust Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 neutralization second vaccination Sex subject T cell response T cell responses the receptor-binding domain vaccination Vaccine vaccine group vector vector vaccine. venous blood was collected were used [DOI] 10.1128/spectrum.02495-21 PMC 바로가기
Performance of 22 Rapid Lateral Flow Tests for SARS-CoV-2 Antigen Detection and Influence of “Variants of Concern”: Implications for Clinical UseArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Alpha Antigen clinical collected coronavirus Cutoff cycle threshold detect detection evaluate evaluated exhibited false-positive result False-positive results Flow head-to-head assessment influence Lateral lateral-flow tests less majority NAAT nucleic acid amplification Occurrence Omicron variant Omicron variants other variants Paris performance proportion ranged Rapid reduced required SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 viral sensitivity Sensitivity and specificity specificity symptom onset Test tested variants variants of concern variants of concern. Viral load Viral variants virus VoC [DOI] 10.1128/spectrum.01157-22 PMC 바로가기
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA ThresholdsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody assay standardization assays authorization can be used CCP clinical trials Clinical use Cohort collected comparable Concordance consequence convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma criteria Cutoff cutoff value Donor drug Emergency Emergency use authorization EUA Expanded Access Program FDA FDA EUA FIVE food high-titer CCP high-titer convalescent plasma highlight hospitalized patients identification identify immunosuppressed patients indicate Limited lowest monoclonal antibody multiple serological assay Pandemics Pathogens positive precluded provided ranged reduce released Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic serologic assay serological Serological assay serological assays serology Serology. serum sample significantly Standardization therapeutic therapeutic option therapy threshold Treatment [DOI] 10.1128/spectrum.01154-22 PMC 바로가기